Orexigen Therapeutics

Metabolics

Orexigen Therapeutics

US biopharma company Orexigen Therapeutics (Nasdaq: OREX) is a biopharmaceutical company focused on the treatment of obesity.

US biopharma company Orexigen Therapeutics (Nasdaq: OREX) is a biopharmaceutical company focused on the treatment of obesity.

The company's lead product candidate is Contrave, which has completed Phase III clinical trials and for which a New Drug Application has been submitted and reviewed by the FDA.

Contrave is a fixed-dose combination of bupropion sustained-release (SR) and Orexigen´s proprietary SR version of naltrexone, designed to improve drug tolerability. The company has also reached agreement with the FDA on a Special Protocol Assessment (SPA) for the Light Study, the Contrave cardiovascular outcomes trial.

The company's other product candidate, Empatic, has completed Phase II clinical trials. Empatic is Orexigen’s second late-stage, investigational medication for weight loss. It is a fixed-dose combination of a proprietary formulation of zonisamide sustained release (SR) and bupropion SR.


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