Prenatal vitamin A deficiency tied to postnatal asthma

12-02-2014 EurekAlert!Comments (0)

BiotechnologyRespiratory and PulmonaryUSA

Researchers have found the first direct evidence of a link between prenatal vitamin A deficiency and postnatal airway hyperresponsiveness, a hallmark of asthma. The study, conducted in mice, shows that short-term deficit of this essential vitamin while the lung is forming can cause profound changes in the smooth muscle that surrounds the airways, causing the adult lungs to respond to environmental or pharmacological stimuli with excessive narrowing of airways. The findings were published online in the Journal of Clinical Investigation.

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