5-HT4 drugs will provide next generation of GI medications
A scientific review published in the journal Neurogastroenterology and Motility suggests that, due to their improved selectivity, 5-HT4 receptor targeting compounds will form the basis for next-generation of gastrointestinal motility disorder and chronic constipation treatments.
Belgian drugmaker Movetis, which was involved in the research project, said that, while it is well known that 5-HT4 drugs have potential for motility disorders, the lack of specificity of older agents and the associated side effects had hampered research. The firm went on to say that newer 5-HT4 products, such as its drug Resolor (prucalopride), have vastly improved receptor specificity.
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