$7.7 MILL GENZYME TRANSGENICS JV

1 May 1994

Genzyme Transgenics, a majority- owned subsidiary of Genzyme Corp, has reported that the parties involved in its Japanese joint venture, SMI Genzyme Ltd, have committed up to a further $7.7 million in additional capital to fund development and marketing of transgenically-produced proteins.

SMI Genzyme has agreed to fund both a new three-year technology development and a two-year program at Genzyme Transgenics for preclinical development of recombinant human antithrombin III in the milk of transgenic goats. The company expects AT-III to be the first transgenically produced product to begin human clinical trials, targeted for late 1995. The product is currently available in a form derived from human plasma.

Genzyme Transgenics also announced five new commercial collaborations for recombinant therapeutic, diagnostic and processing proteins. These are:

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