Australian drug developer Alchemia has entered into a drug-discovery agreement with Melbourne-based SDP Technology to develop anticancer drugs targeting the enzyme sphingosine kinase 1 (SK1) using Alchemia's VAST chemistry.
Under the terms of the deal, SDP will have rights to the structural data from the initial screen and to develop molecules using Alchemia's VAST chemistry. In exchange for these, Alchemia will be granted 5% of the fully-diluted equity in SDP with a further equal tranche of shares and options if a molecule based on its chemistry is advanced into the clinic.
SDP has screened a library of compounds synthesized by Alchemia that are specifically designed to inhibit the kinase family of enzymes. As a result, SDP has identified a number of compounds with promising activity against SK1. More detailed analysis of those compounds is now underway.
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