Biogen beefs up MS portfolio with license to orelabrutinib

13 July 2021

US biotech major Biogen (Nasdaq: BIIB) has entered into a license and collaboration agreement for orelabrutinib, an oral small molecule Bruton’s tyrosine kinase inhibitor (BTKi) for the potential treatment of multiple sclerosis (MS), with China’s InnoCare Pharma (HKEX: 09969).

Orelabrutinib is a covalent BTKi with high selectivity and the ability to cross the blood-brain barrier, and is currently being studied in a multi-country, placebo-controlled Phase II trial in relapsing-remitting MS. The drug has received regulatory approval in China for two cancer indications: the treatment of patients with relapsed/refractory chronic lymphocytic leukemia (R/R CLL)/small lymphocytic lymphoma (R/R SLL), and the treatment of patients with relapsed/refractory mantle cell lymphoma (R/R MCL).

Deal could earn InnoCare up to nearly a billion dollars

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