Astra Pharmaceuticals has launched its calcium channel blocker Plendil (felodipine) onto the market in Germany for the first-line treatment of hypertension. The compound is claimed to have superior vascular selectivity to other calcium antagonists, and no adverse effects on the heart.
Felodipine has been shown to be more effective than monotherapy with hydro-chlorothiazide, nifedipine, nitrendipine and enalapril in the management of uncomplicated hypertension, and has also proved effective in the management of hypertensives with concomitant diseases, such as diabetes, kidney disease, obstructive pulmonary disease, hyperlipidemia, cardiac insufficiency and angina pectoris. It is currently registered in 26 countries.
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