Anglo-Swedish drug major AstraZeneca has launched its once-daily Seroquel XR (quetiapine fumarate) extended-release tablets in the USA for the acute treatment of the depressive episodes associated with bipolar disorder and the manic and mixed episodes associated with bipolar I disorder, as well as the maintenance treatment of bipolar I disorder as adjunctive therapy to lithium or divalproex.
The agent is also now available in two new tablet strengths, 50mg and 150mg. Once-daily Seroquel XR is the only US-approved medication for the treatment of acute depressive, manic and mixed episodes of bipolar disorder.
Approximately eight million American adults may be affected by bipolar disorder, also known as manic-depressive illness, a serious psychiatric condition characterized by recurring episodes of depression and mania. For many patients with bipolar disorder, the depressive symptoms are more disruptive than the manic symptoms.
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