Axsome Phase III program of AXS-05 in Alzheimer’s disease agitation

31 December 2024

US CNS specialist Axsome Therapeutics (Nasdaq: AXSM) yesterday announced the completion of its Phase III clinical program evaluating AXS-05 (dextromethorphan-bupropion), a novel, oral, investigational NMDA receptor antagonist, sigma-1 agonist, and aminoketone CYP2D6 inhibitor, in Alzheimer’s disease agitation, and results of the ACCORD-2, ADVANCE-2, and long-term safety trials in this indication.

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