Based on positive Phase II data, Germany's Bayer Schering Pharma has received ethical approval from the Cambridgeshire Research Ethics Committee in the UK to begin a Phase III program for its oral agent riociguat. Two late-stage studies will investigate the drug in patients with both chronic thromboembolic pulmonary hypertension and pulmonary arterial hypertension. Riociguat is the first member of a new class of therapeutics that stimulate soluble guanylate cyclase.
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