Biogen and Elan start testing Tysabri in first cancer setting with Ph I/II trial in MM
Irish biotechnology company Elan and USA-based Biogen Idec have initiated the first clinical trial of Tysabri (natalizumab) in oncology.
The first dose of the humanized monoclonal antibody, which is approved to treat Crohn's disease and multiple sclerosis, was given as part of a Phase I/II study in patients with relapsed or refractory multiple myeloma.
The drug targets the adhesion molecule VLA4 (also known as alpha-4 integrin) that is expressed on the surface of many types of immune cells. VLA4 is also found on the surface of MM cells and may be involved in their survival.
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