ADC Therapeutics tumbles as LOTIS-5 safety concerns overshadow Zynlonta PFS win

4 June 2026

Shares in Switzerland-based ADC Therapeutics (NYSE: ADCT) fell sharply in pre-market trading on Thursday after investors focused on safety findings and the lack of a clear overall survival advantage in the Phase III LOTIS-5 trial of Zynlonta (loncastuximab tesirine-lpyl) plus rituximab in relapsed or refractory diffuse large B-cell lymphoma (DLBCL).

The company said the study met its primary endpoint, with Zynlonta plus rituximab significantly improving progression-free survival (PFS) compared with rituximab plus gemcitabine and oxaliplatin. Median PFS was 6.1 months versus 4.7 months, with a hazard ratio of 0.73.

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