Agios selects AG-881 for clinical development with Celgene

1 May 2015

US cancer metabolism specialist Agios Pharmaceuticals (Nasdaq: AGIO) says it plans to advance into clinical development AG-881, a small molecule that has shown in preclinical studies to fully penetrate the blood brain barrier and inhibit isocitrate dehydrogenase-1 (IDH1) and IDH2 mutant cancer models.

Development of AG-881 will be in collaboration with its cancer metabolism partner Celgene Corp (Nasdaq: CELG). The companies have entered into a new joint worldwide development and profit share collaboration for AG-881 and plan to initiate clinical development of AG-881 in the second quarter of 2015. AG-881 will be the third IDH mutant inhibitor discovered by Agios to enter clinical development.

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