
Immune-mediated diseases specialist Alumis (Nasdaq: ALMS) has announced positive top-line results from its Phase III ONWARD1 and ONWARD2 trials of envudeucitinib, a next-generation highly selective oral tyrosine kinase 2 (TYK2) inhibitor, in moderate-to-severe plaque psoriasis.
Shares in the US firm closed 95% higher Tuesday, with envudeucitinib meeting all primary and secondary endpoints with high statistical-significance in ONWARD1 and ONWARD2.
In each of these trials, envudeucitinib achieved superior skin clearance compared with placebo on the co primary endpoints of psoriasis area and severity index (PASI) 75 and static physician’s global assessment (sPGA) 0/1 at week 16.
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