Amgen reports positive results from Phase III trial of evolocumab for high cholesterol
USA-based biotech company Amgen (Nasdaq: AMGN) has revealed positive top-line Phase III results for its investigational drug evolocumab (AMG145) in patients with high cholesterol.
The MENDEL-2 trial met its co-primary endpoints: the percentage reduction from baseline in low-density lipoprotein cholesterol (LDL-C) at week 12 and the mean percent reduction from baseline in LDL-C at weeks 10 and 12. The mean percent reductions in LDL-C, or "bad" cholesterol, compared to placebo and ezetimibe were consistent with results observed in the MENDEL Phase II study. Evolocumab is an investigational fully human monoclonal antibody that inhibits proprotein convertase subtilisin/kexin type 9 (PCSK9), a protein that reduces the liver's ability to remove LDL-C from the blood.
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