Amgen’s Phase III DeLLphi-305 study deliverers strong results
US biotech major Amgen (Nasdaq: AMGN) has announced landmark results from the Phase III DeLLphi-305 study, which met its primary endpoint at a pre-specified interim analysis, demonstrating a statistically-significant and clinically-meaningful improvement in overall survival with Imdelltra (tarlatamab-dlle) in combination with AstraZeneca’s (LSE: AZN) Imfinzi (durvalumab) compared to durvalumab alone.
This study tested Imdelltra as a first-line maintenance treatment for people with extensive stage small cell lung cancer (ES-SCLC) whose disease had not progressed following initial treatment with durvalumab, platinum-based chemotherapy and etoposide. The study also demonstrated a statistically-significant and clinically meaningful improvement in progression-free survival (PFS) and objective response rate (ORR) among patients treated with Imdelltra in combination with durvalumab.
This article is accessible to registered users, to continue reading please register for free. A free trial will give you access to exclusive features, interviews, round-ups and commentary from the sharpest minds in the pharmaceutical and biotechnology space for a week. If you are already a registered user please login. If your trial has come to an end, you can subscribe here.
Login to your accountTry before you buy
Free
7 day trial access
- All the news that moves the needle in pharma and biotech
- Exclusive features, podcasts, interviews, data analyses and commentary from our global network of life sciences reporters.
- Receive The Pharma Letter daily news bulletin, free forever.
Become a subscriber
£820
Or £77 per month
- Unfettered access to industry-leading news, commentary and analysis in pharma and biotech.
- Updates from clinical trials, conferences, M&A, licensing, financing, regulation, patents & legal, executive appointments, commercial strategy and financial results.
- Daily roundup of key events in pharma and biotech.
- Monthly in-depth briefings on Boardroom appointments and M&A news.
- Choose from a cost-effective annual package or a flexible monthly subscription
The Pharma Letter is an extremely useful and valuable Life Sciences service that brings together a daily update on performance people and products. It’s part of the key information for keeping me informed
Chairman, Sanofi Aventis UK
More on this story...
Today's issue
Company Spotlight
More Features in Biotechnology
| Headless Content Management with Blaze