ASH: Positive Phase III clinical trial results for Pfizer’s Hympavzi

8 December 2025

US pharma giant Pfizer (NYSE: PFE) presented results from the Phase III BASIS study evaluating Hympavzi (marstacimab) for adults and adolescents living with hemophilia A or B with inhibitors.

The results demonstrated the superiority of Hympavzi in improving key bleeding outcomes compared to on-demand (OD) treatment with bypassing agents. Hympavzi was administered with a straightforward, once-weekly subcutaneous injection requiring minimal preparation and no treatment-related lab monitoring.

The findings were shared in an oral presentation at the 67th American Society of Hematology (ASH) Annual Meeting and Exposition in Orlando and published in Blood.

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