Bavencio plus Inlyta extends median PFS in advanced RCC patients

18 February 2019

The combination of Bavencio (avelumab) and Inlyta(axitinib) significantly extended median progression-free survival (PFS) by more than five months compared with Sutent (sunitinib) as a first-line treatment for patients with advanced renal cell carcinoma (RCC), irrespective of PD-L1 expression (HR: 0.69 [95% CI: 0.56–0.84]; Bavencio+Inlyta: 13.8 months [95% CI: 11.1-NE]; Sutent: 8.4 months [95% CI: 6.9-11.1]; p<0.001).

The results from an interim analysis of the pivotal JAVELIN Renal 101 trial are published online in the New England Journal of Medicine, said Germany’s Merck KGaA (MRK: DE) and its partner on the research, US pharma giant Pfizer (NYSE: PFE), over the weekend. Inlyta and Sutent are both Pfizer-developed drugs.

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