BeOne Meds new Phase III survival data reinforcing benefit of Ziihera

1 September 2026

Sino-American oncology-focused biotech BeOne Medicines (Nasdaq: ONC) has announced positive top-line results from the second interim analysis (IA2) of the Phase III HERIZON-GEA-01 trial evaluating Ziihera (zanidatamab), in combination with chemotherapy, with and without Tevimbra (tislelizumab), as first-line treatment for HER2+ locally advanced or metastatic gastroesophageal adenocarcinoma (GEA).

At IA2, Ziihera plus chemotherapy demonstrated a statistically -significant and clinically-meaningful improvement in overall survival (OS) compared with trastuzumab plus chemotherapy, meeting the remaining primary endpoint analysis of the study.

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