CatalYm ready to build on impressive visugromab data
It is becoming evident that German oncology start-up CatalYm has a highly promising asset on its hands in the shape of visugromab, a first-in-class anti-growth differentiation factor-15 (GDF-15) antibody.
Data presented last year at the European Society of Medical Oncology (ESMO) Congress 2025 added to the excitement.
Firstly, there were the compelling primary results from the Phase II GDFATHER-NEO trial, showing that GDF-15 blockade by visugromab enhanced the efficacy of PD-1 inhibition by nivolumab as a neoadjuvant therapy in muscle-invasive bladder cancer (MIBC), with a similar safety profile compared to nivolumab plus placebo.
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