Celldex drops Phase II study of barzolvolimab in prurigo nodularis

22 July 2026

US immunology specialist Celldex (Nasdaq: CLDX) yesterday reported mixed top-line results from the company’s Phase II study of barzolvolimab delivered subcutaneously in prurigo nodularis (PN), a chronic skin disease that causes hard, intensely itchy lumps/nodules to form on the skin.

The primary endpoint of the study, the proportion of patients who achieve a four point or greater improvement in WI-NRS (Worst Itch Numeric Rating Scale) from baseline to Week 12, and key secondary endpoints were not met.

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