Eisai and Nuvation Bio ink licensing deal for taletrectinib

16 January 2026

Japan’s Eisai (TYO: 4523) has reached a license agreement with Nuvation Bio (NYSE: NUVB), a global oncology company focused on tackling some of the toughest challenges in cancer treatment, that significantly expands the long-term global footprint of Ibtrozi (taletrectinib) in the USA and Japan.

Taletrectinib is a highly selective, next-generation oral treatment currently approved for patients living with advanced ROS1-positive (ROS1+) non-small cell lung cancer (NSCLC) in the USA, China, and Japan. Ibtrozi generated net product revenue of $15.7 million for the fourth quarter, bringing the total to $24.7 million since its launch in June last year. Nuvation’s shares fell nearly 18% on the news, which came the same day as its financial results.

According to a report from DelveInsight, the ROS1 inhibitor market size across the USA, Europe, and Japan was worth around $290 million in 2023, with the USA representing the largest share.

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