Evommune's EVO756 misses primary endpoint in atopic dermatitis Phase IIb

10 September 2026

US biotech Evommune (NYSE: EVMN) has said its oral MRGPRX2 antagonist EVO756 failed to meet its primary or secondary endpoints in a Phase IIb trial in moderate-to-severe atopic dermatitis (AD), and that it does not plan to advance the candidate further in the indication.

The randomized, double-blind, placebo-controlled, dose-ranging trial enrolled 121 adults over a 12-week treatment period, with follow-up through week 14, testing EVO756 against placebo across multiple doses.

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