Hyperion terminates DaiPep277 program due to "misconduct"

8 September 2014

Shares of Hyperion Therapeutics’ (Nasdaq: HPTX) plunged 11% to $24.61 in pre-market trading today, after the company announced it is terminating development of DiaPep277 for newly diagnosed type 1 diabetes.

The company has uncovered evidence that certain employees of Israel-based Andromeda Biotech, which  Hyperion acquired for what could have been nearly $600 million from Clal Biotechnology Industries (CBI: TA), engaged in serious misconduct, including collusion with a third-party biostatistics firm in Israel to improperly receive un-blinded DIA-AID 1 trial data and to use such data in order to manipulate the analyses to obtain a favorable result. The up-front payment was $20 million in cash and stock and there was a potential $550 million more in milestones.

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