Impressive data for once-daily sofosbuvir and ledipasvir treatment of HCV genotype 1
Strong results from three Phase III clinical trials (ION-1, ION-2 and ION-3) evaluating the investigational once-daily fixed-dose combination of the nucleotide analogue polymerase inhibitor sofosbuvir (SOF) 400mg and the NS5A inhibitor ledipasvir (LDV) 90mg, with and without ribavirin (RBV), for the treatment of genotype 1 chronic hepatitis C virus (HCV) infection have been presented at the International Liver Congress2014, held by the European Association for the Study of Liver Disease (EASL) in London, UK.
This was further good news for US anti-viral specialist Gilead Sciences (Nasdaq: GILD), which has also reported results of trails with its potential blockbuster hepatitis C drug Sovaldi (sofosbuvir) in other setting at this meeting, and had already seen its shares jump 4% to $68.11 on Friday (The Pharma Letters passim).
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