Intellia shares leap as FDA lifts trial hold
Gene editing company Intellia Therapeutics (Nasdaq: NTLA) has announced that the US Food and Drug Administration (FDA) has removed the clinical hold on the Investigational New Drug application (IND) for the MAGNITUDE-2 Phase III trial of nexiguran ziclumeran (nex-z) for patients with hereditary transthyretin amyloidosis with polyneuropathy (ATTRv-PN).
The news led shares in the US firm, which is focused on developing CRISPR-based therapies, to jump by 9% during Tuesday morning’s early trading.
Initially, the FDA placed MAGNITUDE-2 on hold in October after a patient experienced a dangerous increase in liver enzymes following treatment.
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