JAK inhibitors dealt blow with FDA review outcome

2 September 2021

A US Food and Drug Administration (FDA) review of a large clinical trial has led the agency to conclude that JAK inhibitors lead to an increased risk of serious heart-related events such as heart attack or stroke, cancer, blood clots, and death.

The trial compared Pfizer’s (NYSE: PFE) arthritis and ulcerative colitis medicines Xeljanz (tofacitinib) and Xeljanz XR (tofacitinib), which fall in the JAK inhibitor class, and another type of drug called tumor necrosis factor (TNF) blockers, in patients with rheumatoid arthritis.

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