MHRA approves Kostaive mRNA COVID-19 vaccine

2 January 2026

The UK’s Medicines and Healthcare products Regulatory Agency (MHRA) has today approved Kostaive (zapomeran) mRNA COVID-19 vaccine, for the immunization of individuals aged 18 years of age and older.

Kostaive (ARCT-154), a self-amplifying mRNA COVID-19 vaccine, was developed Australia’s CSL Limited (ASX: CSL) and licensed to US sa-mRNA pioneer Arcturus Therapeutics (Nasdaq: ARCT).

Zapomeran is given as a single 0.5mL booster dose by injection into the muscle of the upper arm. It contains a self-amplifying messenger RNA (sa-mRNA) which instructs the body’s cells to temporarily make the SARS-CoV-2 spike protein. This teaches the immune system to fight off the virus in the future.

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