
US biotech VistaGen Therapeutics (Nasdaq: VTGN) has presented data highlighting the proposed mechanism of action (MOA) of its Phase III investigational drug candidate, PH94B nasal spray at the Anxiety and Depression Association of America’s 2021 Virtual Annual Conference.
PH94B is designed with potential to provide rapid-onset acute treatment of anxiety for millions of individuals suffering from social anxiety disorder (SAD) without directly activating gamma-amino butyric acid (GABA-A) receptors. PH94B’s MOA is, therefore, fundamentally differentiated from the MOA of benzodiazepines such as alprazolam, diazepam and lorazepam, which are direct GABA-A receptor positive modulators.
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