NGM Bio leaps on positive top-line aldafermin trial in NASH

25 February 2020

US biotech NGM Biopharmaceuticals (Nasdaq: NGM) yesterday announced positive preliminary top-line results for its liver disease candidate aldafermin, sending the firm’s shares rocketing 23.5% to $20.00 in heavy volume by Monday mid-morning, having jumped as much as 41%.

The results were from the 24-week double-blind, randomized, placebo-controlled cohort (Cohort 4) of an adaptive Phase II study evaluating the efficacy, safety and tolerability of 1mg aldafermin (formerly NGM282) in patients with biopsy-confirmed non-alcoholic steatohepatitis (NASH) with stage 2 or 3 liver fibrosis (F2-F3).

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