Novartis' remibrutinib hits primary endpoint in Phase III multiple sclerosis trials

1 September 2026

Swiss pharma giant Novartis (NOVN: VX) said its Phase III REMODEL-1 and REMODEL-2 trials of remibrutinib met their primary endpoint, significantly reducing annualized relapse rate compared with teriflunomide in adults with relapsing multiple sclerosis (RMS), according to top-line results announced Tuesday.

Remibrutinib also showed superiority over teriflunomide on all key secondary endpoints in each trial, including reduction of MRI lesions.

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