Oculis OCS-01 eye drops miss primary endpoints in Phase III trials

30 May 2026

Swiss drug developer Oculis Holding (Nasdaq: OCS) announced top-line results from its Phase III DIAMOND-1 and DIAMOND-2 trials of OCS-01 eye drops in patients with diabetic macular edema (DME)., which disappointed, sending the firm’s shares tumbling 32% to $15.40 in after-market trading on Friday.

The DIAMOND (DIAbetic Macular edema patients ON a Drop) program consisted of two Phase III, double-masked, randomized, multicenter trials to evaluate the efficacy and safety of OCS-01 eye drops in patients with DME following 52 weeks of treatment. Over 800 patients were enrolled across both pivotal trials at 119 investigational sites throughout the USA and several other countries.

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