Phase III trial of oral ALZ 801 in patients with early Alzheimer's disease
Privately-held US neurology specialist Alzheon today announced the dosing of the first patient in its APOLLOE4 Phase III study evaluating the efficacy and safety of ALZ-801 in early AD patients carrying two copies of the ε4 allele of the apolipoprotein E gene (APOE4/4 homozygotes).
AD patients with this genetic profile present with an early onset and rapid progression of the disease and are responsive to drug agents that remove or inhibit pathogenic amyloid oligomers. ALZ-801 is an oral treatment that has been shown in pre-clinical mechanistic studies to fully inhibit the formation of neurotoxic soluble beta amyloid oligomers at the Phase III clinical dose.
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