Positive new data on Roche’s Lunsumio and Polivy combo

23 June 2025

Swiss pharma giant Roche (ROG: SIX) has released encouraging results from the Phase III SUNMO study showing Lunsumio (mosunetuzumab) administered subcutaneously in combination with Polivy (polatuzumab vedotin), delivered a seismic update in aggressive lymphoma therapy.

The study demonstrated a clinically-meaningful and statistically-significant improvement in its primary endpoints of progression-free survival (PFS) and objective response rate (ORR) compared to MabThera/Rituxan (rituximab), gemcitabine and oxaliplatin (R-GemOx), in people with relapsed or refractory (R/R) large B-cell lymphoma (LBCL) who are not eligible for transplant. Primary analysis data were featured at the 18th International Conference on Malignant Lymphoma as a late-breaking oral presentation.

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