Positive Ph III Tezspire data eosinophilic esophagitis
Positive high-level results from the Phase III CROSSING trial in patients with eosinophilic esophagitis (EoE) showed that AstraZeneca (LSE: AZN) and Amgen’s (Nasdaq: AMGN) Tezspire (tezepelumab) demonstrated statistically-significant and clinically-meaningful improvements across both co-primary and all key secondary endpoints at week 24, which were sustained through week 52 in both doses tested.
The co-primary endpoints were histologic remission and the frequency and severity of dysphagia (difficulty swallowing) compared to placebo. The safety profile of Tezspire in the trial was generally consistent with its approved indications.
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