Positive Phase III trial results for Cytokinetics’ Myqorzo
US cardiovascular biotechCytokinetics (Nasdaq: CYTK) has presented full results from ACACIA-HCM, the pivotal Phase III trial of Myqorzo (aficamten) in symptomatic non-obstructive HCM (nHCM), in the Hot Line 1 session at ESC Congress 2026 in Munich. Results were simultaneously published in The New England Journal of Medicine.
ACACIA-HCM met both dual primary endpoints, demonstrating statistically significant improvements from baseline to Week 36 compared to placebo in both Kansas City Cardiomyopathy Questionnaire Clinical Summary Score (KCCQ-CSS) and maximal exercise performance (pVO2). Results for the dual primary endpoint analysis consistently favored aficamten across prespecified subgroups studied.
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