Strong efficacy in Phase III for Pfizer/Valneva’s Lyme disease vaccine

23 March 2026

US pharma giant Pfizer (NYSE: PFE) and French vaccine maker Valneva (Euronext Paris: VLA) today announced top-line results from the Phase III VALOR "Vaccine Against Lyme for Outdoor Recreationists" clinical trial of its investigational 6-valent OspA-based Lyme disease vaccine candidate PF-07307405 (LB6V, formerly known as VLA15).

In the pre-specified analyses of the much anticipated study: efficacy was 73.2% from 28 days post-dose 4 (season 2) in reducing the rate of confirmed Lyme disease cases compared to the placebo arm (95% CI 15.8, 93.5); and efficacy was 74.8% from 1-day post-dose 4 (season 2) in reducing the rate of confirmed Lyme disease cases compared to the placebo arm (95% CI 21.7, 93.9).

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