The week in pharma: action, reaction and insight – week to January 2, 2026

4 January 2026

By Barbara Obstoj-Cardwell. Editor

In a slow news last week a mixed batch of clinical trials results featured. First, US biotech Ultragenyx announced disappointing Phase III results for its Osteogenesis Imperfecta (OI) candidate setrusumab, under development with Mereo BioPharm. Then InflaRx presented a new analysis of vilobelimab for pyoderma gangrenosum, and Pfizer disclosed a death in a long term Hympavzi study after thrombotic stroke. Also of note, after previous setbacks, the US Food and Drug Administration (FDA) granted approval for Vanda Pharmaceuticals’ motion sickness drug Nereus (tradipitant).

Disappointing setrusumab outcome

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