Vera's Trutakna shows two-year kidney protection in final ORIGIN 3 analysis
US biotech Vera Therapeutics (Nasdaq: VERA) said its BAFF and APRIL inhibitor Trutakna (atacicept-vymj) met all prespecified endpoints in the final efficacy analysis of the Phase III ORIGIN 3 trial in adults with primary IgA nephropathy (IgAN) at risk of disease progression, with two years of follow-up data.
In the 428-patient final analysis, mean estimated glomerular filtration rate (eGFR) declined by just 0.1 mL/min/1.73m2 with Trutakna at 52 weeks, against 5.7 with placebo, a placebo-adjusted difference of 5.6.
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