Zenbexus doubles MRD-negative complete response rate in pivotal myeloma trial
Bristol Myers Squibb (NYSE: BMY) has presented detailed results from the pivotal Phase III EXCALIBER-RRMM trial showing Zenbexus (iberdomide) in combination with daratumumab and dexamethasone (ZDd) roughly doubled minimal residual disease (MRD)-negative complete response rates against daratumumab, bortezomib and dexamethasone (DVd) in relapsed or refractory multiple myeloma.
The results, presented at the International Myeloma Society's annual meeting in Glasgow, Scotland, were simultaneously published in The Lancet Oncology.
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