Breakthrough designation for Tecentriq plus Avastin in liver cancer

19 July 2018

Swiss pharma giant Roche (ROG: SIX) has been awarded a Breakthrough Therapy badge for a combination of Tecentriq (atezolizumab) and Avastin (bevacizumab) against hepatocellular carcinoma (HCC) in the first-line setting.

HCC is the most common form of liver cancer. Roche has been trialling a combination of its checkpoint inhibitor, Tecentriq, with its anti-VEGF biologic, Avastin, in a Phase Ib trial, results from which were presented at the annual meeting of the American Society of Clinical Oncology (ASCO) in June.

Those results showed that after a median follow-up of 10.3 months, responses were seen in 15 of 23 “efficacy-evaluable” patients.

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