Dupixent demonstrated superiority over Xolair in chronic rhinosinusitis
French pharma major Sanofi (Euronext: SAN) and US partner Regeneron Pharmaceuticals (Nasdaq: REGN) yesterday presented positive results from the EVEREST Phase IV study of adults with severe chronic rhinosinusitis with nasal polyps (CRSwNP) and coexisting asthma.
In the study, Dupixent (dupilumab) outperformed Roche’s (ROG: SIX) Xolair (omalizumab) on all primary and secondary efficacy endpoints of CRSwNP, and in all asthma-related endpoints. The data are from the first-ever presented head-to-head respiratory study with biologic medicines and were shared today in a late-breaking oral presentation at the 2025 European Academy of Allergy and Clinical Immunology (EAACI) Annual Congress, Glasgow, UK.
Dupixent, for which global net sales reached around 13.1 billion euros ($14.1 billion) last year in all its indications, is already Sanofi’s biggest-selling drug that has received regulatory approvals in more than 60 countries in one or more indications.
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