Earlier use of Carvykti pays off in Phase III multiple myeloma trial

30 January 2023

Positive results from the Phase III CARTITUDE-4 study show the novel BCMA-directed T-cell therapy Carvykti (ciltacabtagene autoleucel) performed well in the treatment of multiple myeloma.

Together with Legend Biotech (Nasdaq: LEGN), fellow USA-based drugmaker Johnson & Johnson (NYSE: JNJ) is developing the therapy for relapsed and lenalidomide-refractory disease.

The trial compared Carvykti, which was approved by the US regulator one year ago as an option after four or more lines of therapy, with two standard-of-care regimens that included pomalidomide.

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