Gilead's Sovaldi and velpatasvir combination achieves high rates of virologic response at 12 weeks
US biotech major Gilead Sciences (Nasdaq: GILD) has reported high rates of virologic response at 12 weeks across all six genotypes of hepatitis C in trials of its drug Sovaldi (sofosbuvir) and velpatasvir.
The ASTRAL-1, ASTRAL-2 and ASTRAL-3 studies consisted of 1,035 patients with hepatitis C infection who received treatment with Sovaldi and velpatasvir for 12 weeks. The company found that 21% of the patients in the trials had compensated cirrhosis, and 28% had failed prior treatments.
Norbert Bischofberger, executive vice president of R&D and chief scientific officer at Gilead, said that the results from the ASTRAL studies "demonstrate that a 12-week course of therapy with the first fixed-dose combination of two pan-genotypic compounds can provide high cure rates for patients with all HCV genotypes."
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