ICER to evaluate CAR-T therapies in upcoming report

20 July 2017

The USA-based not-for-profit Institute for Clinical and Economic Review (ICER) will develop a report assessing the comparative clinical effectiveness and value of chimeric antigen receptor T-cell (CAR-T) therapies for treatment of certain types of cancer.

The report is tentatively expected to consider two therapies currently under review by the US Food and Drug Administration: axicabtagene ciloleucel, from US biotech firm Kite Pharmaceuticals (Nasdaq: KITE), and tisagenlecleucel-t, from Swiss pharma giant Novartis (NOVN: VX).

If approved, axicabtagene ciloleucel is expected to be used in the treatment of relapsed or refractory aggressive non-Hodgkin’s lymphoma in adult patients who are not eligible for autologous stem cell transplant. An approval decision is expected in December of 2017, following a Biologics License Application filing in April.

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