Immatics’ ESMO data primes PRAME-targeted attack on cancer

Germany-based Immatics (Nasdaq: IMTX) has this month announced updated clinical data from its PRAME-directed TCR T-cell therapy, anzu-cel (anzutresgene autoleucel, IMA203), in 16 patients with metastatic uveal melanoma.

Results from the ongoing Phase Ib trial, presented at the ESMO Congress 2025 during the Presidential Symposium III, showed compelling and durable anti-tumor activity as well as a favorable tolerability profile in what is a difficult-to-treat patient population.

‘Remarkable’ data

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