J&J ends development of Imaavy alongside anti-TNFα therapy for RA

1 September 2025

Johnson & Johnson (NYSE: JNJ) is to cease development of Imaavy (nipocalimab) in combination with UCB’s (Euronext: UCB) anti-TNFα therapy Cimzia (certolizumab pegol) for rheumatoid arthritis (RA).

The US healthcare giant made the announced as it revealed the results of the Phase IIa DAISY proof-of-concept study, having identified that this combination in RA patients with refractory disease was an innovative approach with the potential to be an effective option in this difficult-to-treat population.

At 12 weeks, study results did not show sufficient evidence that the combination therapy provided significant added benefit over anti-TNFα therapy alone.

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