Keytruda combo could unlock potential of arenaviral tech

2 June 2023

Phase II results from Austrian arenaviral technology firm Hookipa Pharma (Nasdaq: HOOK) show a 43% objective response rate (ORR) for its lead candidate in head and neck cancer.

Hookipa is testing HB-200, an alternating 2-vector immunotherapy, in combination with Keytruda (pembrolizumab), for people with recurrent/metastatic Human Papillomavirus 16-positive (HPV16+) cancer.

The ORR is double the 19% observed for Keytruda alone, and the firm said it would aim to kick off a pivotal trial for the combo, in the first-line setting, next year.

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