Kite’s Yescarta shows real-world benefit in LBCL

12 June 2025

US antivirals specialist Gilead Sciences’ (Nasdaq: GILD) Kite, unit today presented the latest results that demonstrate a 79% overall response rate (ORR) and 74% overall survival (OS) at six months follow-up, for Yescarta (axicabtagene ciloleucel) as second-line treatment for relapsed/refractory (R/R) large B-cell lymphoma (LBCL), from the largest real-world study in this patient population.

Yescarta, a CAR-T therapy that was first approved in the USA in 2017, is already an important earner for Gilead, generated sales of $386 million in the first quarter of this year, up 2%.

Globally, the CAR T-cell therapy market was valued at $3.7 billion in 2023 and is projected to grow to $5.5 billion in 2024. Analysts forecast expansion to $29 billion by 2029, driven by rising demand, new approvals, and broader application beyond blood cancers.

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