Lyell boosts pipeline with acquisition of novel CAR T therapy
US biotech Lyell Immunopharma (Nasdaq: LYEL) has broadened its cell therapy portfolio by acquiring global rights to LYL273, a guanylyl cyclase-C (GCC)-targeted CAR T candidate from Innovative Cellular Therapeutics.
The therapy, designed for metastatic colorectal cancer and other GCC-expressing tumors, showed a 67% overall response rate and an 83% disease control rate at the highest dose tested in a Phase I US trial.
The candidate, previously known as GCC19CART, uses controlled cytokine release and CD19 CAR expression to enhance immune cell infiltration and tumor killing in the solid tumor microenvironment.
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